Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  2
• Reference
  J:119260 Lan H, et al., Dimension reduction for mapping mRNA abundance as quantitative traits. Genetics. 2003 Aug;164(4):1607-14
• ID
  MGI:3702979

Genes

Gene	Assay Type
Dbmc1	visible phenotype
D2Mit106	PCR amplified length variant

Notes

• Experiment
  A genome wide scan was performed on 108 (BTBR x C57BL/6J) F2-ob/ob intercross animals, using 192 polymorphic markers, to identify loci affecting liver mRNA expression of 7 metabolic genes in correlation with diabetes traits. Male (BTBR x C57BL/6J) F1 hybrid animals develop severe hyperglycemia while neither parental strain exhibits diabetes or obesity phenotypes.
  
  Linkage to Scd1, Fas, and Gpat expression with the insulin trait mapped to 66 cM on mouse Chromosome 2 near D2Mit106 (LOD=7.7). This locus spans approximately 60 cM - 90 cM and is named Dbmc1 (diabetes mRNA cluster 1). Scd1 expression accounts for the majority of the effect at Dbmc1, with BTBR-derived alleles conferring dominantly inherited increased Scd1 expression. T2dm3 is a previously identified insulin QTL mapping near Dbmc1.
  
  Linkage to Scd1, Fas, and Gpat expression with the insulin trait mapped to 60 cM on mouse Chromosome 5 near D5Mit240 (LOD=4.5). This locus spans approximately 40 cM - 60 cM and is named Dbmc2 (diabetes mRNA cluster 2). Again, Scd1 expression accounts for the majority of the effect at Dbmc2, with BTBR-derived alleles conferring dominantly inherited increased Scd1 expression.
  
  Dbmc3 (diabetes mRNA cluster 3) mapped to mouse Chromosome 9. C57BL/6J-derived alleles at Dbmc3 confer increased Scd1 expression with dominant inheritance.