Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  6
• Reference
  J:122134 Smit-McBride Z, et al., A strong genetic determinant of hyperoxia-related retinal degeneration on mouse chromosome 6. Invest Ophthalmol Vis Sci. 2007 Jan;48(1):405-11
• ID
  MGI:3714796

Genes

Gene	Assay Type
Hrdg1	resistance/susceptibility
Pon2	reported elsewhere

Notes

• Experiment
  Chromosome substitution strains (CSS) carrying A/J-derived donor chromosomes on a C57BL/6J genetic background were used to identify genetic loci involved in hyperoxia-induced retinal degeneration. Animals were exposed to 75% oxygen for 14 days and sacrificed for outer nuclear layer (ONL) measurements. Parental strain C57BL/6J is susceptible to hyperoxia-induced retinal degeneration compared to parental strain A/J.
  
  B6-Chr 6^A/J displays little or no hyperoxia-induced retinal degeneration similar to donor strain A/J suggesting the presence of a protective QTL on chromosome 6. This QTL is named Hrdg1 (hyperoxia-related retinal degeneration 1). C57BL/6J-derived alleles at Hrdg1 confer susceptibility to hyperoxia-induced retinal degeneration with a dominant or additive mode of inheritance.
  
  Gene expression and SNP analysis were used to identify potential candidate genes on chromosome 6. Pon2 at 1.5 cM is an example of a candidate gene that is expressed in eye tissue and contains SNPs in the 5' UTR region.