Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  7
• Reference
  J:120144 Meng H, et al., Identification of Abcc6 as the major causal gene for dystrophic cardiac calcification in mice through integrative genomics. Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4530-5
• ID
  MGI:3715277

Genes

Gene
Abcc6
Abcc6

Notes

• Experiment
  The authors generated a backcross population between strains HcB24 and C3H (HcB24xC3H) and screened N2 mice for recombinant progeny in a 7-cM interval which included the Dyscalc1 locus . 649 backcross mice yielded 49 recombinants. Analysis of 23 recombinant progeny within this region restricted the Dyscalc1 locus to an 840-kb region containing 38 genes. One of these loci Abcc6 was indicated as the causitive gene for the Dyscalc1 phenotype.