Mapping Data

Experiment

• Experiment
  HYBRID
• Chromosome
  2
• Reference
  J:8437 Sparkes RS, et al., Assignment of the human and mouse prion protein genes to homologous chromosomes. Proc Natl Acad Sci U S A. 1986 Oct;83(19):7358-62
• ID
  MGI:37210

Genes

Gene
Prnp

Notes

• Experiment
  Seven rat x mouse and two hamster x mouse microcell hybrids were typed for Prn-p using hamster PrP cDNA probe pHaPrP-cDNA-1 on Southern blots of EcoRI digested hybrid cell DNA. Of these, three rat x mouse microcell hybrids contained mouse Rb(2.8) [F(2.8)D], no mouse chromosomes [FB(2.8)D, a backselected derivative of F(2.8)D] or mouse Chromosome 8 alone [F(8)D], respectively. These lines conclusively assigned Prn-p to Chromosome 2 by its presence in line F(2.8)D and absence in FB(2.8)D and F(8)D.

HYBRID

• Concordance
  chromosomes

HYBRID Data

Chromosome	+/+	+/-	-/+	-/-
1	0	0	3	6
2	3	0	0	6
3	0	0	3	6
4	0	0	3	6
5	0	0	3	6
6	2	1	1	5
7	2	1	1	5
8	1	3	2	3
9	2	1	1	5
10	1	1	2	5
11	0	2	3	4
12	2	1	1	5
13	0	3	3	3
14	1	2	2	4
15	2	3	1	3
16	1	1	2	5
17	1	0	2	6
18	0	1	3	5
19	0	1	3	5
X	0	1	3	5