Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  3
• Reference
  J:122481 Holler PD, et al., The same genomic region conditions clonal deletion and clonal deviation to the CD8alphaalpha and regulatory T cell lineages in NOD versus C57BL/6 mice. Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7187-92
• ID
  MGI:3723067

Genes

Gene	Assay Type
Tcdel2	visible phenotype

Notes

• Experiment
  Linkage analysis was performed on 91 F2 animals from a (B6.Cg-H2^g7 Tg(TcraBDC2.5)1Doi Tg(TcrbBDC2.5)2Doi x NOD.Cg-Tg(TcraBDC2.5)1Doi Tg(TcrbBDC2.5)2Doi)F2 intercross to identify genetic loci associated with thymocyte clonal deletion. Parental strain NOD.Cg-Tg(TcraBDC2.5)1Doi Tg(TcrbBDC2.5)2Doi displays increased clonal deletion of CD8alphaalpha thymocytes. One hundred twenty SNP markers at a resolution of 19 Mb were genotyped.
  
  A major locus for % double-positive cells and % CD8 alpha alpha cells mapped to 25 cM (50 Mb) on mouse Chromosome 3 with LOD=6.67. This QTL is very tightly linked to Tcdel2 and may represent the same locus. Previously identified diabetes QTL Idd3 (19.2 cM) maps near Tcdel2. Complementation studies between NOD.Cg-Tg(TcraBDC2.5)1Doi Tg(TcrbBDC2.5)2Doi and a line from Taconic Farms named NOD.Idd3R540 suggests that Tcdel2 and Idd3 are independent of one another.
  
  Suggestive linkage to thymocyte clonal deviation mapped to distal mouse Chromosome 1. This locus is tightly linked to a QTL identified in a previous study by the same authors named Tcdel1 (T cell clonal deletion 1), and may represent the same QTL.