Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  3
• Reference
  J:128900 Cha S, et al., Two NOD Idd-associated intervals contribute synergistically to the development of autoimmune exocrinopathy (Sjogren's syndrome) on a healthy murine background. Arthritis Rheum. 2002 May;46(5):1390-8
• ID
  MGI:3769156

Genes

Gene	Assay Type
Aec1	resistance/susceptibility
Il2	reported elsewhere

Notes

• Experiment
  Previously identified diabetes QTLs Idd3 (Chr3) and Idd5 (Chr1) also show linkage to autoimmune exocrinopathy, a symptom of Sjogren's syndrome. Authors investigated the effect of these QTLs in congenic lines carrying NOD/Uf-derived Idd3 and/or Idd5 donor regions on a C57BL/6J genetic background. Parental strain NOD/Uf is susceptible to sialadenitis compared to C57BL/6J. Congenic animals were phenotyped at 12- and 16-weeks of age.
  
  Single congenic lines B6.NOD-Idd3 and B6.NOD-Idd5 did not display significant susceptibility to autoimmune exocrinopathy. However, the double congenic line B6.NOD-Idd3^NOD/Uf Idd5^NOD/Uf displays decreased secretory function starting at 16 weeks of age, decreased salivary flow rates, and reduced amylase activity. Authors noted that the reciprocal congenic line NOD.B6-Idd3^C57BL/6J Idd5^C57BL/6J restored normal secretory function comparable to that of resistant strain C57BL/6J.
  
  The autoimmune exocrinopathy susceptibility locus captured within the Idd3 interval on Chromosome 3 was named Aec1 (autoimmune exocrinopathy1) by the authors. A potential candidate gene is Il2 (19.2 cM).
  
  The susceptibility locus on Chromosome 1 captured within the Idd5 interval was named Aec2. Potential candidate genes for Aec2 include Fn1 (36.1 cM), Igfbp2 (36.1 cM), Igfbp5 (36.1cM), Col6a3 (53.9 cM), Btg2 (71 cM), Il10 (69.9 cM), Lamc1 (81.1 cM), and Lamc2 (81.1 cM).