Mapping Data

Experiment

• Experiment
  TEXT-QTL-Candidate Genes
• Chromosome
  10
• Reference
  J:129298 Kovacs P, et al., Variation of the gene encoding the nuclear bile salt receptor FXR and gallstone susceptibility in mice and humans. J Hepatol. 2008 Jan;48(1):116-24
• ID
  MGI:3769572

Genes

Gene	Assay Type
Lith7	visible phenotype
Nr1h4	reported elsewhere

Notes

• Experiment
  Previously identified gallstone susceptibility QTL Lith7 mapped to 50 cM on mouse Chromosome 10 in a PERA/EiJ (gallstone susceptible) and I/LnJ (gallstone resistant) cross. Nr1h4 (50 cM) was identified as a positional candidate gene. Authors further investigated Nr1h4 by sequence and expression analysis. Several polymorphisms in the 5' and coding region were identified in PERA/EiJ and I/LnJ Nr1h4 sequences. In addition, I/LnJ animals fed a lithogenic diet exhibit increased hepatic expression of Nr1h4 mRNA compared to I/LnJ.