Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  1
• Reference
  J:129916 Cha S, et al., IDD3 and IDD5 alleles from nod mice mediate Sjogren's syndrome-like autoimmunity. Adv Exp Med Biol. 2002;506(Pt B):1035-9
• ID
  MGI:3771038

Genes

Gene	Assay Type
Aec2	resistance/susceptibility
Il1r1	reported elsewhere
Bcl2	reported elsewhere
Casp8	reported elsewhere
Ctla4	reported elsewhere

Notes

• Experiment
  Authors investigated the effects of diabetes susceptibility loci Idd3 (Chr3) and Idd5 (Chr1) on the associated phenotype autoimmune exocrinopathy in B6.NOD-Idd3^NOD/Uf Idd5^NOD/Uf and B6.NOD-Idd5^NOD/Uf congenic animals. Parental strain NOD/Uf displays lymphocyte infiltration of the exocrine glands and loss of salivary secretory function.
  
  The single congenic strain B6.NOD-Idd5^NOD/Uf exhibits autoimmune exocrinopathy but does not display loss of secretory function. This suggests a gene on Chromosome 1 captured within the congenic interval specifically influences lymphocytic infiltration of the exocrine glands. This locus was named Aec2 (autoimmune exocrinopathy 2) in a previous publication. Potential candidate genes located in this interval include Il1r1 (19.5 cM), Bcl2 (59.8 cM), Casp8 (30.1 cM), and Ctla4 (30.1 cM).
  
  In the double congenic B6.NOD-Idd3^NOD/Uf Idd5^NOD/Uf decreased saliva flow was observed at 12 weeks of age. Saliva flow was reduced by 41% compared to 20-week old control C57BL/6J animals. This finding suggests NOD/Uf-derived genes captured in the Idd3 and Idd5 donor intervals recapitulate the salivary dysfunction phenotype of Sjogren syndrome. The locus linked to Idd3 was named Aec1 (autoimmune exocrinopathy 1) in a previous publication. Il2 (19.2 cM) is a possible candidate gene for Aec1.