Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  6
• Reference
  J:137837 Vallois D, et al., Influence of a non-NK complex region of chromosome 6 on CD4+ invariant NK T cell homeostasis. J Immunol. 2008 Aug 1;181(3):1753-9
• ID
  MGI:3804877

Genes

Gene	Assay Type
Idd6	resistance/susceptibility
Idd6.2	resistance/susceptibility
D6Mit13	PCR
D6Mit294	PCR

Notes

• Experiment
  C3H/HeJ alleles at Idd6 (insulin dependent diabetes susceptibility 6) on mouse Chromosome 6 confer protection against diabetes mellitus on a NOD genetic background as previously observed in the congenic line NOD.C3H-Idd6. In the current study authors observe a significant decrease in invariant natural killer (iNKT) cell frequency and numbers in spleen, liver and thymus of NOD.C3H-Idd6 congenics compared to NOD and C3H/HeJ parental strains. In NOD.C3H-Idd6 congenic animals, CD4+ iNTK cell numbers were at30%-50% of the levels seen in NOD animals, and at 20%-25% of the levels seen in C3H/HeJ animals. The pancreas of NOD.C3H-Idd6 congenic mice displayed reduced iNKT cell proportions compared to NOD mice. IL-4 and IFN-gamma secretion following induced cytokine production were also reduced in NOD.C3H-Idd6 animals compared to NOD mice.
  
  Subcongenic lines were analyzed to localize the interval responsible for reduced iNKT cell frequency. Subcongenic lines NOD.C3H-Idd6a and NOD.C3H-Idd6c displayed similar iNKT cell frequencies compared to NOD inbred mice. However, NOD.C3H-Idd6b showed low iNKT cell number and low CD4+/double negative iNKT cell ratios similar to that observed in NOD.C3H-Idd6 congenic animals. Authors conclude the Idd6b locus [from approximately 70cM (D6Mit13) to 73.4 cM (D6Mit294)] influences diabetes resistance as well as iNKT cell population frequencies.