Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  13
• Reference
  J:142770 Stylianou IM, et al., Differences in DBA/1J and DBA/2J reveal lipid QTL genes. J Lipid Res. 2008 Nov;49(11):2402-13
• ID
  MGI:3828429

Genes

Gene	Assay Type
Tgq24	visible phenotype

Notes

• Experiment
  Linkage analysis was performed using a backcross derived from closely related inbred strains DBA/1J and DBA/2J. The genetic composition of these 2 inbred strains differs by just 5.6% at the SNP level. A total of 294 mice from (DBA/1J x DBA/2J)F1 x DBA/1Jand (DBA/1J x DBA/2J)F1 x DBA/2J populations were screened for 6,949 polymorphic SNP markers. Backcross mice were placed on a high-fat diet at 8 weeks of age and phenotyped for plasma triglyceride and HDL concentrations at 8, 11 and 16 weeks of age. Parental strain DBA/2J displays significantly increased plasma triglyceride concentrations on a CHOW diet compared to parental strain DBA/1J. Male DBA/2J animals display significantly increased plasma triglyceride and HDL concentrations after an 8 week high fatdiet compared to DBA/1J males.
  
  Tgq24 (triglyceride QTL 24) mapped to 58 cM on mouse Chromosome 13 with LOD=4.3 at rs3710370 (120.25 Mb) for linkage to plasma triglyceride concentrations in males after 3 weeks on a high fat diet. DBA/2J-derived alleles at Tgq24 confer increased triglyceride levels in males. This locus also displays suggestive linkage to triglycerides on a CHOW diet (LOD=3.7). [Table 2 and 3].