Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  X
• Reference
  J:137289 Kusek GK, et al., Localization of two new X-linked quantitative trait loci controlling corpus callosum size in the mouse. Genes Brain Behav. 2007 Jun;6(4):359-63
• ID
  MGI:3828957

Genes

Gene	Assay Type
Ccrs3	visible phenotype
Ccrs4	visible phenotype

Notes

• Experiment
  Inbred strain BTBR T⁺ tf/J displays total absence of the corpus callosum and severely reduced hippocampal commissure while inbred strain BALB/cByJ displays consistently normal hippocampal commissure and a low incidence of agenesis of the corpus callosum. F1 crosses between BTBR T⁺ tf/J and BALB/cByJ indicate the phenotype is X-linked. Male (BTBR T⁺ tf/J x BALB/cByJ)F1 animals displayed a higher incidence of corpus callosum abnormalities compared to male (BALB/cByJ x BTBR T⁺ tf/J)F1 animals suggesting susceptibility to corpus callosum agenesis is contributed by the BTBR strain. Hippocampal commissure size did not appear to correlate with X chromosome inheritance.
  
  A population of 420 males derived from (BALB/cByJ x BTBR T⁺ tf/J)F1 backcrossed to BALB/cByJ or BTBR T⁺ tf/J were used to map the corpus callosum locus by identifying X chromosome recombination events. Animals were phenotyped at 8 weeks of age. Significant linkage to corpus callosum size mapped to 29.5 cM (68.5 Mb) near rs13483824 (LRS=9.8) and is named Ccrs3 (corpus callosum hemisphere surface size 3). Highly significant linkage to corpus callosum size mapped to 60.5 cM (134.5 Mb) near rs13484035 (LRS=12.4) and is named Ccrs4 (corpus callosum hemisphere surface size 4). BTBR-derived alleles at Ccrs3 and Ccrs4 confer decreased corpus callosum size with dominant inheritance. L1cam (29.5 cM) is a potential candidate gene for Ccrs3 while Dcx (140.29 Mb) is a potential candidate gene for Ccrs4.