Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  12
• Reference
  J:143893 Suto J, Identification of multiple quantitative trait loci affecting the size and shape of the mandible in mice. Mamm Genome. 2009 Jan;20(1):1-13
• ID
  MGI:3832859

Genes

Gene	Assay Type
Mssq11	visible phenotype
D12Mit136	PCR amplified length variant
Mssq12	visible phenotype
D12Mit158	PCR amplified length variant

Notes

• Experiment
  Genetic loci affecting mandible size and shape were mapped using 190 mice from a (C57BL/6JJcl x KK-A^y/TaJcl)F2 intercross. Of the F2 population, 97 animals had the A^y/a genotype and 93 animals had the a/a genotype. Thirteen measurements taken from the right mandible and 3 principal components were assessed in experimental animals 6-7 months of age. Parental strain KK-A^y/TaJcl displays increased values across most of the 13 mandible measurements compared to parental strain C57BL/6JJcl. The A^y allele increases mandible size in KK animals compared to the a allele. A panel of 100 polymorphic markers was used for linkage analysis.
  
  Significant linkage to principal component 3 (PC3) mapped to two positions on mouse Chromosome 12 in the combined F2 population. Mssq11 (mandible size and shape QTL 11) is located at 13 cM near D12Mit136 (LOD=5.2) and Mssq12 (mandible size and shape QTL 13) is located at 38 cM near D12Mit158. KK-derived alleles at both QTL confer increased PC3 values for mandible size. This locus also displays suggestive linkage to PC3 in the A^y/a F2 group (LOD=2.5). Gsc (52 cM) is a possible candidate gene for Mssq12.