Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  12
• Reference
  J:144089 Su Z, et al., Genetic basis of HDL variation in 129/SvImJ and C57BL/6J mice: importance of testing candidate genes in targeted mutant mice. J Lipid Res. 2009 Jan;50(1):116-25
• ID
  MGI:3840077

Genes

Gene	Assay Type
Hdlq18	visible phenotype

Notes

• Experiment
  Linkage analysis was performed on 528 animals from a (C57BL/6J x 129S1/SvImJ)F2 intercross to map QTL associated with plasma HDL levels on either a CHOW or atherogenic diet. F2 animals were fed a CHOW diet until 8 weeks of age and then placed on an atherogenic diet until 16 weeks of age. An array of 508 SNPs was used for genome scan. Plasma HDL is significantly higher in 129S1/SvImJ parental strain compared to C57BL/7J on CHOW and high fat diets, with a stronger effect observed in males compared to females. Several previously identified HDL QTL were detected in this study as well as several novel loci, some of which showed interactive effects.
  
  Hdlq18 (HDL QTL 18) on mouse Chromosome 12 displayed interaction with a novel locus on mouse Chromosome 19 named Hdlq59. Homozygosity for C57BL/6J-derived alleles at Hdlq18 and Hdlq59 confers significantly decreased plasma HDL concentration in animals fed a CHOW diet. Hdlq18 maps to 11.5 Mb (3 cM) near rs3717933. Hdlq59 is located at 47.2 Mb (47 cM) on chromosome 19 near rs3023496.