Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  3
• Reference
  J:147462 Norgard EA, et al., Replication of long-bone length QTL in the F(9)-F (10) LG,SM advanced intercross. Mamm Genome. 2009 Apr;20(4):224-35
• ID
  MGI:3847079

Genes

Gene	Assay Type
Lbn3a	visible phenotype
Lbn3b	visible phenotype
Lbn3c	visible phenotype
Lbn3d	visible phenotype

Notes

• Experiment
  Advanced intercross lines derived from LG/J and SM/J parental inbred strains at the F9 (n=150) and F10 (n=1305) generations were used to confirm and refine previously identified QTL (from F2-F3 generations) for long bone traits and identify novel geneticloci and interacting QTL. Animals were phenotyped between 12 and 40 weeks of age and genotyped at 1470 polymorphic SNP loci. The average distance between markers is 1.66 Mb. Long bone measurements were taken for the right-side tibia, femur, humerus and ulna. Eighty-one single-trait QTL were detected in this study, which includes 27 previously identified long bone loci. Thirteen novel pleiotropic loci were detected.
  
  On mouse Chromosome 3, previously identified QTL Lbn3 was refined into three separate loci. Lbn3a (long bones 3a) mapped to 30 cM near rs13477144 in linkage to femur length (LPR=5.95). Pleiotropic QTL Lbn3b (long bones 3b) mapped to 48 cM near rs13477279 in linkage to humerus (LPR=7.85), femur (LPR=6.71), ulna (LPR=6.9) and tibia (LPR=4.15) lengths with significantly greater linkage in females compared to males. Lbn3c (long bones 3c) mapped to 55 cM near rs3676545. Lbn3c displays linkage to humerus (LPR=7.02; female-specific trait), ulna (LPR=7.82; more significant in females), femur (LPR=6.14; female-specific trait) and tibia lengths (LPR=5.4; more significant in females). A novel locus named Lbn3d (long bones 3d) mapped to 76 cM near rs13477477 in linkage to humerus length (LPR=4.78).