Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  4
• Reference
  J:147462 Norgard EA, et al., Replication of long-bone length QTL in the F(9)-F (10) LG,SM advanced intercross. Mamm Genome. 2009 Apr;20(4):224-35
• ID
  MGI:3847082

Genes

Gene	Assay Type
Lbn11	visible phenotype

Notes

• Experiment
  Advanced intercross lines derived from LG/J and SM/J parental inbred strains at the F9 (n=150) and F10 (n=1305) generations were used to confirm and refine previously identified QTL (from F2-F3 generations) for long bone traits and identify novel geneticloci and interacting QTL. Animals were phenotyped between 12 and 40 weeks of age and genotyped at 1470 polymorphic SNP loci. The average distance between markers is 1.66 Mb. Long bone measurements were taken for the right-side tibia, femur, humerus and ulna. Eighty-one single-trait QTL were detected in this study, which includes 27 previously identified long bone loci. Thirteen novel pleiotropic loci were detected.
  
  A novel pleiotropic locus associated with all four bone traits mapped to approximately 42.5 cM on mouse Chromosome 4 near rs13477831. This locus is designated Lbn11 (long bones 11). Lbn11 is linked to tibia length (LPR=7.4), femur length (LPR=7.47), humerus length (LPR=4.36) and ulna length (LPR=10.28). Association of Lbn11 with humerus length displays super-significant linkage in females.