Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  8
• Reference
  J:147462 Norgard EA, et al., Replication of long-bone length QTL in the F(9)-F (10) LG,SM advanced intercross. Mamm Genome. 2009 Apr;20(4):224-35
• ID
  MGI:3847086

Genes

Gene	Assay Type
Lbn7a	visible phenotype
Lbn7b	visible phenotype

Notes

• Experiment
  Advanced intercross lines derived from LG/J and SM/J parental inbred strains at the F9 (n=150) and F10 (n=1305) generations were used to confirm and refine previously identified QTL (from F2-F3 generations) for long bone traits and identify novel geneticloci and interacting QTL. Animals were phenotyped between 12 and 40 weeks of age and genotyped at 1470 polymorphic SNP loci. The average distance between markers is 1.66 Mb. Long bone measurements were taken for the right-side tibia, femur, humerus and ulna. Eighty-one single-trait QTL were detected in this study, which includes 27 previously identified long bone loci. Thirteen novel pleiotropic loci were detected.
  
  On mouse Chromosome 8, previously identified QTL Lbn7 was detected at 33 cM near rs13479811. This locus is reassigned to Lbn7a (long bones 7a) and displays linkage to tibia length (LPR=4.9) in males and ulna length (LPR=6.41) in both sexes. A novel QTL named Lbn7b (long bones 7b) mapped to proximal chromosome 8 at 4 cM near rs6287472. Lbn7b displays linkage to ulna (LPR=4.67) and tibia (LPR=5.16) lengths.