Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  9
• Reference
  J:147462 Norgard EA, et al., Replication of long-bone length QTL in the F(9)-F (10) LG,SM advanced intercross. Mamm Genome. 2009 Apr;20(4):224-35
• ID
  MGI:3847087

Genes

Gene	Assay Type
Lbn8b	visible phenotype
Lbn8c	visible phenotype

Notes

• Experiment
  Advanced intercross lines derived from LG/J and SM/J parental inbred strains at the F9 (n=150) and F10 (n=1305) generations were used to confirm and refine previously identified QTL (from F2-F3 generations) for long bone traits and identify novel geneticloci and interacting QTL. Animals were phenotyped between 12 and 40 weeks of age and genotyped at 1470 polymorphic SNP loci. The average distance between markers is 1.66 Mb. Long bone measurements were taken for the right-side tibia, femur, humerus and ulna. Eighty-one single-trait QTL were detected in this study, which includes 27 previously identified long bone loci. Thirteen novel pleiotropic loci were detected.
  
  Two novel bone length loci were identified on mouse Chromosome 9. Lbn8b (long bones 8b) mapped to 43 cM near rs3670195 and displays linkage to ulna (LPR=7.52) and tibia (LPR=3.88) lengths. Lbn8c (long bones 8c) is a single-trait QTL mapping to 61 cM near rs3723953. This QTL displays linkage to humerus length with LPR=5.45.