Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  10
• Reference
  J:147462 Norgard EA, et al., Replication of long-bone length QTL in the F(9)-F (10) LG,SM advanced intercross. Mamm Genome. 2009 Apr;20(4):224-35
• ID
  MGI:3847090

Genes

Gene	Assay Type
Lbn9a	visible phenotype
Lbn9b	visible phenotype

Notes

• Experiment
  Advanced intercross lines derived from LG/J and SM/J parental inbred strains at the F9 (n=150) and F10 (n=1305) generations were used to confirm and refine previously identified QTL (from F2-F3 generations) for long bone traits and identify novel geneticloci and interacting QTL. Animals were phenotyped between 12 and 40 weeks of age and genotyped at 1470 polymorphic SNP loci. The average distance between markers is 1.66 Mb. Long bone measurements were taken for the right-side tibia, femur, humerus and ulna. Eighty-one single-trait QTL were detected in this study, which includes 27 previously identified long bone loci. Thirteen novel pleiotropic loci were detected.
  
  Previously mapped QTL Lbn9 was detected in this study at 47 cM on mouse Chromosome 10 near rs13480684. This locus is reassigned Lbn9a (long bones 9a) and displays linkage to humerus (LPR=8.22) and femur (LPR=5.34) lengths. A novel QTL designated Lbn9b (long bones 9b) mapped to 70 cM near rs6290842. This locus displays linkage to ulna (LPR=13.16) and tibia (LPR=9) lengths.