Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  16
• Reference
  J:147462 Norgard EA, et al., Replication of long-bone length QTL in the F(9)-F (10) LG,SM advanced intercross. Mamm Genome. 2009 Apr;20(4):224-35
• ID
  MGI:3847100

Genes

Gene	Assay Type
Lbn15	visible phenotype

Notes

• Experiment
  Advanced intercross lines derived from LG/J and SM/J parental inbred strains at the F9 (n=150) and F10 (n=1305) generations were used to confirm and refine previously identified QTL (from F2-F3 generations) for long bone traits and identify novel geneticloci and interacting QTL. Animals were phenotyped between 12 and 40 weeks of age and genotyped at 1470 polymorphic SNP loci. The average distance between markers is 1.66 Mb. Long bone measurements were taken for the right-side tibia, femur, humerus and ulna. Eighty-one single-trait QTL were detected in this study, which includes 27 previously identified long bone loci. Thirteen novel pleiotropic loci were detected.
  
  A novel pleiotropic QTL named Lbn15 (long bones 15) mapped to 62 cM on mouse Chromosome 16 near rs4219239. Lbn15 is linked to humerus length in males (LPR=6.48) and ulna length (LPR=10.81) with greater significance in males compared to females.