Mapping Data

Experiment

• Experiment
  TEXT-QTL-Candidate Genes
• Chromosome
  19
• Reference
  J:149028 Holdt LM, et al., Increased ADAM17 mRNA expression and activity is associated with atherosclerosis resistance in LDL-receptor deficient mice. Arterioscler Thromb Vasc Biol. 2008 Jun;28(6):1097-103
• ID
  MGI:3850381

Genes

Gene	Description
Ascla5
Adam17	exon 19 SNP

Notes

• Experiment
  Refined QTL mapping using a subset of F2 mice from the C57BL/6J-Ldlr^tm1Her X FVB/N-Ldlr^tm1Her cross (J:104621) was informative in mapping a Adam17 exon 19 SNP significantly to a the region identified as Ascla5(J:104621). The LOD score associated with the exon 19 SNP was 4.2.