Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  13
• Reference
  J:149041 Kulikov AV, et al., Genetic structure of hereditary catalepsy in mice. Genes Brain Behav. 2008 Jun;7(4):506-12
• ID
  MGI:3850448

Genes

Gene
Catys1
D13Mit78

Notes

• Experiment
  QTL mapping using congenic lines in this experiment confirmed the location of Catys1 to mouse Chromosome 13 (J:88524) and further refined its location to a 10 cM region. CBA/lacJ are catalepsy-prone whereas AKR/J mice are catalepsy resistant. Three congenic mouse lines (AKR.CBAD13Mit76C,AKR.CBA-D13Mit76A and AKR.CBA-D13Mit78)carrying from between 59 and 75 cM fragments from mouse Chromosome 13 derived from the CBA to the AKR genome were created via the backcrossing of (CBA X AKR)F1 on AKR strain. These aformantioned Congenic lines proved informative in mapping catalepsy to mose Chromosome 13. In a genome wide scan using 48 markers polymorphic between AKR/J and CBA/lacJ the Catys1 locus was confirmed to be in mouse Chromosome 13 between 61 and 70- cMand associated near D13Mit78. The Chromosome 13 gene accounted for 20% of the trait penetrance.