Mapping Data

Experiment

• Experiment
  TEXT-Genetic Cross
• Chromosome
  2
• Reference
  J:10399 Woychik RP, et al., Molecular and genetic characterization of a radiation-induced structural rearrangement in mouse chromosome 2 causing mutations at the limb deformity and agouti loci. Proc Natl Acad Sci U S A. 1990 Apr;87(7):2588-92
• ID
  MGI:39071

Genes

Gene	Allele	Assay Type	Description
Fmn1	Grem1^ld	Southern analysis
Is(17;In2)1Gso		Southern analysis	3'ld
a		visible phenotype

Notes

• Reference
  Revised gene symbol: Fmn (formerly ld). ld is an allele of Fmn.
• Experiment
  Mapping of radiation induced alleles, ld^In2 and a^In2 using cytogenetic and molecular analysis demonstrated that a complex rearrangement Is(17;In2)ld a^j 1Gso had occurred. This rearrangement joined the Fmn1 locus to a region at or near the agouti locus and caused sequence disruptions in both loci resulting in mutations. The Fmn1 locus was disrupted at a breakpoint near its 3' end. A probe derived from the region 3' of the lFmn1d breakpoint was followed in a M. spretus backcross and did not recombinewith agouti (0/93) demonstrating that this sequence is normally tightly linked with agouti.