Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  15
• Reference
  J:9343 Amari NM, et al., Reverse genetics approaches for cloning RIL-1, a major locus involved in susceptibility to leukemia. Curr Top Microbiol Immunol. 1988;137:256-63
• ID
  MGI:39086

Genes

Gene	Assay Type	Description
Ril5	resistance/susceptibility	susceptibility to radiation induced leukemia
H30	reported elsewhere
Ril6	resistance/susceptibility	susceptibility to radiation induced leukemia
Ly6	reported elsewhere

Notes

• Experiment
  Measurement of Ril1 mediated radiation-induced leukemia susceptibility in congenic strains demonstrated that Ril1 is on Chromosome 15. Evidence from congenic strain pairs included high susceptibility in B6.C-H30^c and lower susceptibility in C57BL/6JBy,suggesting linkage of Ril1 and H30 and high susceptibility in C3H.B6-Ly-6^b and lower susceptibility in C3H/HeJ suggesting linkage of Ril1 and Ly6.
  
  10.19.2015 Curator Note: Because Ril1 was originally mapped in J:6610,in 1981 to Chr 2 using an (A/J x C57BL/10ScSn)F2 intercross, we consider the congenics used here to be mapping unique QTL. We have labeled the QTL identified using the B6.C-H30^c congenics as Ril5; and the QTL identified using the C3H.B6-Ly-6^b congenics as Ril6.