Mapping Data

Experiment

• Experiment
  TEXT-Genetic Cross
• Chromosome
  13
• Reference
  J:8855 Hadchouel M, et al., Maternal inhibition of hepatitis B surface antigen gene expression in transgenic mice correlates with de novo methylation. Nature. 1987 Oct 1-7;329(6138):454-6
• ID
  MGI:39247

Genes

Gene	Assay Type	Description
Hbvi	Southern analysis	4/12

Notes

• Reference
  Revised gene symbol: Hbvi (formerly D13Pas2).
• Experiment
  Two transgenic male mice, Tg(OHBV)E11-Pas (E11) and Tg(13HBV)E36-Pas (E36) have similar hepatitis B viral (HBV) DNA sequences in their genome. These mice differ in the genetic transmission of hepatitis B surface antigen expression. The E36 insertion was cloned and a flanking probe identified, that detected a polymorphism useful in screening a SPE/Pas and C57BL/6JPas backcross. The locus identified, Hbvi, mapped to Chromosome 13 and displayed imprinting whereby passage through the female germ line resulted in methylation of the transgenic HBV sequences.