Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  17
• Reference
  J:9065 Reckelhoff JF, et al., Mep-1, the gene regulating meprin activity, maps between Pgk-2 and Ce-2 on mouse chromosome 17. Immunogenetics. 1988;27(4):298-300
• ID
  MGI:39448

Genes

Gene
H2-D1
H2-Q2
H2-T18
Pgk2
Mep1a
Ce2

Notes

• Reference
  Revised gene symbol: H-2Q2 (formerly Qa-2).
• Experiment
  The position for the locus of gene Mep1 relative to Pgk2 and Ce2 on Chromosome 17 was determined by analysis of 9 sets of recombinant phenotypes derived from B10.K9(Mep1^b/Mep1^b), B10.D2(Mep1^a/Mep1^a) or Ma/My(Mep1^b/Mep1^b parents. Recombinant B10.KR2 (parents B10.D2 and B10.K) exhibited the Mep1^b and Pgk2^a alleles of the B10.K parent and the Ce2^a allele of the B10.D2 parent. This recombination indicates that the locus for Mep1 must lie between Pgk2 and Ce2. Four strains other than B10.KR2showed recombination between Mep1 and Pgk2, positioning Mep1 distal to Pgk2 and thus proximal to Ce2. A total of 681 progeny were analyzed and the 1 recombination (in B10.KR2) between Mep1 and Ce2 represents a genetic distance of .07 cM. An order of -centromere- H-2D, H-2Q2, H2-T18, Pgk2, Mep1 and Ce2 on Chromosome 17 was suggested by analysis of all 9 sets of recombinants.