Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  7
• Reference
  J:1953 Hanada K, et al., Immune responses in newly developed short-lived SAM mice. IV. Chromosomal location of a gene controlling defective helper T-cell activity. Immunology. 1991 Sep;74(1):160-4
• ID
  MGI:40499

Genes

Gene	Allele	Assay Type
Tyr	Tyr^c	visible phenotype
Lar		immunological

Notes

• Experiment
  Genetic linkage of low antibody response (Lar) with the albino locus on mouse Chromosome 7 was determined in 296 (B10.BR x SAMP1)F2 mice. Parental strain SAMP1 exhibits low antibody response when challenged with sheep or horse red blood cells whereas parental strain B10.BR exhibits normal antibody response. From a total of 72 albino mice 15 (20%) were low responders, whereas only 18 of 206 (8.0%) nonalbino mice were lowresponders. The correlation data provides a chi-square of 9.00 with a P of less than .01. Low antibody response in F2 animals shows linkage to Tyr (44 cM) on mouse Chromosome 7.