Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  7
• Reference
  J:1953 Hanada K, et al., Immune responses in newly developed short-lived SAM mice. IV. Chromosomal location of a gene controlling defective helper T-cell activity. Immunology. 1991 Sep;74(1):160-4
• ID
  MGI:40500

Genes

Gene	Assay Type
Lar	immunological
Gpi1	electrophoretic

Notes

• Experiment
  Genetic linkage of low antibody response (Lar) with the Gpi1 locus on mouse Chromosome 7 was determined in 208 (B10.BR x SAM-P/1)F2 mice. Parental strain SAMP1 exhibits low antibody response when challenged with sheep or horse red blood cells whereas parental strain B10.BR exhibits normal antibody response. From a total of 24 low responders, 9 (37%) carried the Gpi-1 a/a genotype of the SAM-P/1 parent. Whereas of a 184 responders only 39 (21%) carried the SAM-P/1 Gpi-1 genotype. The correlation data aprovides a chi-square of 8.21 with a P of less than .01. Low antibody response in F2 animals shows linkage to Gpi1 (11 cM) on mouse Chromosome 7.