Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  2
• Reference
  J:1371 Hess EJ, et al., Spontaneous locomotor hyperactivity in a mouse mutant with a deletion including the Snap gene on chromosome 2. J Neurosci. 1992 Jul;12(7):2865-74
• ID
  MGI:40541

Genes

Gene	Assay Type	Description
Bmp2
Snap25	Southern analysis	SNAP-25 probe
Cm	visible phenotype
Pax1

Notes

• Experiment
  Examination of +/+ and Cm/+ mice by Southern blot analysis indicated that the Cm mutation is a deletion of Snap. These data show approximately 50% lower levels of mRNA and protein in Cm/+ mice as compared to +/+. Further, (+/+ M. spretus x Cm/+ M. m. musculus)F1 mice that were Cm/+ lacked the M. m. musculus bands in RFLP analysis. Analysis of Bmp2 and Pax1 show that these two loci are not included in the Snap-Cm deletion.