Mapping Data

Experiment

• Experiment
  TEXT-Genetic Cross
• Chromosome
  15
• Reference
  J:2964 Thomas KR, et al., Swaying is a mutant allele of the proto-oncogene Wnt-1. Cell. 1991 Nov 29;67(5):969-76
• ID
  MGI:41347

Genes

Gene	Allele	Assay Type	Description
Wnt1	Wnt1^sw	molecular technique	pMT25

Notes

• Reference
  sw is an allele of Wnt1.
• Experiment
  The recessive gene sw (swaying) was shown to be a mutation at the Wnt1 locus through allelism testing using the wnt1^neo allele that was created by the insertion of the bacterial neoⁿ into the second exon of Wnt1. A heterozygous +/sw male was mated with heterozygous +/wnt1^neo females. From this cross seven of the 34 progeny died after birth. These seven mice were identical in phenotype to wnt1^neo mutant homozygotes indicating that sw and Wnt1 are allelic. The sw allele is thus Wnt1^sw. Molecular analysis of the Wnt1^sw allele indicates that the mutation is a single base (guanosine) deletion in the third exon of Wnt1.