Mapping Data

Experiment

• Experiment
  TEXT-Genetic Cross
• Chromosome
  12
• Reference
  J:3053 McGrath J, et al., Duplication/deficiency mapping of situs inversus viscerum (iv), a gene that determines left-right asymmetry in the mouse. Genomics. 1992 Nov;14(3):643-8
• ID
  MGI:41395

Genes

Gene	Assay Type
T(5;12)31H	visible phenotype
Dnah11	visible phenotype

Notes

• Experiment
  The iv mutation was mapped distal to the T(5;12)31H breakpoint on Chromosome 12. Using duplication/deficiency mapping analysis. Of the potential progeny from a T31H/+ x iv/iv cross, one mouse was monosomic for the large 5¹² translocated chromosome and expressed the iv/iv phenotype. Other partially trisomic mice that carried the small translocated 12⁵ chromosome were mated to iv/iv mice. Progeny from this cross that carried the small 5¹² chromosome (29/57) did not express iv, whereas 6 of 28 mice that did not carry 5¹² did express iv/iv. Thus the normal iv allele was located on distal Chromosome 12 in the region contained by the 5¹² translocation product.