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Mapping Data
Experiment
  • Experiment
    HYBRID
  • Chromosome
    11
  • Reference
    J:7538 Killary AM, et al., A genetic analysis of extinction: trans-dominant loci regulate expression of liver-specific traits in hepatoma hybrid cells. Cell. 1984 Sep;38(2):523-34
  • ID
    MGI:41397
Genes
GeneAlleleAssay TypeDescription
Prkar1a enzyme activity extinction of TAT expression
Notes
  • Experiment
    Six somatic cell hybrid and 8 microcell hybrid lines derived from rat hepatoma x mouse embryonic fibroblast cells were analyzed. Among the microcell hybrids 4 contained only mouse Chromosome 11, 3 contained mouse Chromosome 11 and a few additional mouse chromosomes and 1 contained only mouse Chromosome X. All 7 microcell hybrids containing Chromosome 11 were positive for Tse-1. Six of these microcell hybrids were backselected to eliminate mouse Chromosome 11 and these back-selectants were all negative for Tse-1, confirming the assignment of Tse-1 to Chromosome 11. Presence of Tse-1 was determined by extinction of TAT expression. Chromosomes were identified by G-banding.
HYBRID
  • Concordance
    chromosomes
HYBRID Data
Chromosome +/+ +/- -/+ -/-
1 5 0 7 2
2 3 0 9 2
3 2 0 10 2
4 2 0 10 2
5 3 0 9 2
6 3 0 9 2
7 3 0 9 2
8 5 0 7 2
9 6 1 6 1
10 5 1 7 1
11 12 0 0 2
12 3 0 9 2
13 7 1 5 1
14 3 1 9 1
15 5 1 7 1
16 4 0 8 2
17 2 0 10 2
18 2 1 10 1
19 2 0 10 2
X 3 2 9 0
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory