Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  7
• Reference
  J:4101 Nicholls RD, et al., Evaluation of potential models for imprinted and nonimprinted components of human chromosome 15q11-q13 syndromes by fine-structure homology mapping in the mouse. Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):2050-4
• ID
  MGI:41579

Genes

Gene	Assay Type	Description
Myod1	Southern analysis	MYOD1 cDNA2
Herc2	Southern analysis	MN7
Oca2	visible phenotype
Mkrn3	Southern analysis	34-1-111
Gabrb3	Southern analysis	218/219

Notes

• Reference
  DN34 was used as a probe to isolate both a genomic clone (which hybridizes to D7Hms1) and a cDNA 34-1-111 (which hybridizes to D7H15S9-1 now called Zfp127). Since they are closely linked in humans and 34-1-111 recognizes the DN34 homolog in mouse, the authors suggest that D7Hms1 and D7H15S9-1 are identical.
• Experiment
  Based on deletion mapping, the p^46DFiOD mutation includes Myod1 and the entire D7H15S12/p transcription unit. The p^4THO-11 deletion breaks within D7H15S12 and includes Gabrb3. D7H15F37S1 is deleted in p^6H and p^7FR60Lb and in prenatal lethal mutations p^3R0M and p^46DFiOD. Locus D7H15S9-1 is located outside of these p deletions.