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Mapping Data
Experiment
  • Experiment
    TEXT
  • Chromosome
    17
  • Reference
    J:1094 Miyazawa M, et al., Detailed mapping of the Rfv-1 gene that influences spontaneous recovery from Friend retrovirus-induced leukaemia. Eur J Immunogenet. 1992 Jun;19(3):159-64
  • ID
    MGI:41829
Genes
GeneAlleleAssay TypeDescription
H2-D1 histocompatibility
Rfv1 resistance/susceptibility
Notes
  • Experiment
    Rfv-1 was mapped to the D region of H-2 using congenic and recombinant mouse strains. (B6 x A.By)F1 is homozygous b/b at H-2D and is resistant to Friend leukemia virus 1. (B6.C-H-2bm14 x A.By)F1, (B10.A x A.By)F1, (B10.A(18R) x A.By)F1, (B10.MBR x A.By)F1, (B10.BR x A.By)F1 and (B10.D2/n x A.By)F1 all have a heterozygous H-2D region and are susceptible to the virus. A transgenic strain, D8 (homozygous d/d in the D region), when made heterozygous for H-2D showed a minor inhibitory effect on recovery from FV leukemia. Since the presence of a non-Db allele correlates with susceptibility and homozygous Db mice are resistant, the authors conclude that Rfv-1 maps to the D region of H-2.

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory