Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  17
• Reference
  J:7573 Bond JS, et al., Mep-1 gene controlling a kidney metalloendopeptidase is linked to the major histocompatibility complex in mice. Proc Natl Acad Sci U S A. 1984 Sep;81(17):5542-5
• ID
  MGI:41885

Genes

Gene	Assay Type
H2-D1	reported elsewhere
Mep1a	enzyme activity
Pgk2	reported elsewhere

Notes

• Experiment
  To map the Mep-1 gene to Chromosome 17 meprin activity was analyzed in various inbred, congenic and H-2 recombinant congenic strains. All meprin deficient strains were of the H-2^k haplotype with the exceptions of C58/J and C57BR/cd which were H-2^k but had normal meprin activity. Recombinant congenic C3H.A/HaDv was meprin positive and recombinant between H-2E and H-2S, carrying C3H alleles for the proximal H-2 region. C3H.OH/SfDv and C3H.OL/SfDv were meprin negative and were recombinant between H-2S and H-2D (C3H.OH) or between H-2D and Qa-2 (C3H.OL), carrying DBA/2J alleles for the proximal H-2 region. This evidence places Mep-1 distal to H-2S. In further analysis of recombinant chromosomes, Mep-1 was localized between H-2D and Upg-1, with the best correlation with Pgk-2 among the inbred strains analyzed.