Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  15
• Reference
  J:8044 Wirschubsky Z, et al., Gene localization on sorted chromosomes: definitive evidence on the relative positioning of genes participating in the mouse plasmacytoma-associated typical translocation. Proc Natl Acad Sci U S A. 1985 Oct;82(20):6975-9
• ID
  MGI:41965

Genes

Gene	Assay Type	Description
Myc	Southern analysis	Ryc7.4 and Exon 1-Myc
Pvt1	Southern analysis	probe B

Notes

• Experiment
  Flow sorted mouse chromosomes from plasmacytoma cell line X24C were used to demonstrate that the decapitated Myc gene, which is evident in reciprocal T(12;15) of X24C, is orientated such that Exon 1 of Myc remains on Chromosome 12 with exons 3 and 4 translocating to Chromosome 15. These results indicate that the 5' end of Myc must orientate towards the centromere on Chromosome 15. Authors also indicate that the Pvt-1 locus translocates with Myc to Chromosome 15. This provides evidence that Pvt-1 is telomeric to and lies 3' of Myc.