Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  17
• Reference
  J:3240 Brownstein DG, et al., Serial backcross analysis of genetic resistance to mousepox, using marker loci for Rmp-2 and Rmp-3. J Virol. 1992 Dec;66(12):7073-9
• ID
  MGI:42290

Genes

Gene	Assay Type	Description
H2-D1	other	microcytotoxicity assay
Rmp6	resistance/susceptibility

Notes

• Experiment
  Confirmation of linkage between H2-D and Rmp3 on mouse Chromosome 17 was established. (C57BL/6NCr x DBA/2NCr)F1 female mice were backcrossed to DBA/2NCr male mice deriving an N2 founder male of the genotype H2-D^b Rmp3^r with the C57BL/6 allele H-2D^bbeing a marker for the Rmp3 resistant phenotype. Data derived from the concordant passage of these two genes through seven generations of backcrosses to DBA/2NCr suggest a recombination frequency of 0.2 to 0.3 between H2-D and Rmp3.
  
  10.8.2015 Curator Note: Rmp3 was orginally mapped using a (C57BL/6J x DBA/2J)F1 x DBA/2J backcross in 1991 in J:11032. A second cross in the same study identified QTL Rmp6 using
  a (C57BL/6NCr x DBA/2NCr)F1 x DBA/NCr backcross population. We have equated the map study here as confirming Rmp6.