Mapping Data

Experiment

• Experiment
  TEXT-Genetic Cross
• Chromosome
  7
• Reference
  J:15460 Qiao JH, et al., Involvement of the tyrosinase gene in the deposition of cardiac lipofuscin in mice. Association with aortic fatty streak development. J Clin Invest. 1993 Nov;92(5):2386-93
• ID
  MGI:42543

Genes

Gene	Allele	Assay Type
Tyr	Tyr^c	visible phenotype

Notes

• Reference
  The albino locus encodes tyrosinase.
• Experiment
  Cardiac lipofuscin in mice was found to completely cosegregate with the albino (c) locus on mouse Chromosome 7 as indicated in F1 and F2 crosses involving B6.C.H^25c and BALB/cJ mice. Tyrosinase (tyr) which is coded for at the albino locus directly affects the cardiac lipofuscin phenotype as indicated by the analysis of C57BL/6J -c^2J/c^2J and C57BL/6J -c^2J/+ mice. Multiple genetic factors may contribute to the cardiac lipofuscin phenotype in mice.