Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  4
• Reference
  J:15703 Dietrich WF, et al., Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse. Cell. 1993 Nov 19;75(4):631-9
• ID
  MGI:42671

Genes

Gene	Assay Type	Description
D4Mit13	PCR amplified length variant	M169
Pla2g2a	PCR amplified length variant	MAPC MT, MAPC15
D4Mit16	PCR amplified length variant	A65

Notes

• Experiment
  The genetic mapping of a quantitative trait, Mom1 (modifier of Min1), was accomplished using 3 intraspecific backcrosses, C57BL/6J x (AKR/J x C57BL/6-Min)F1, C57BL/6J x (Ma/MyJ x C57BL/6-Min)F1, C57BL/6J x (CAST/Ei x C57BL/6-Min)F1; the simple sequence length polymorphisms (SSLP); and number of mice which exhibited multiple neoplasia tumors. Based on genetic analysis and statistical significance, Mom1 appears to reduce the number of tumors by 12, and maps to mouse Chromosome 4 in the interval between D4Mit13 and D4Mit16 with a LOD score of 14.0 at the peak.