Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  17
• Reference
  J:10869 Teuscher C, et al., Experimental allergic orchitis in mice. VI. Recombinations within the H-2S/H-2D interval define the map position of the H-2-associated locus controlling disease susceptibility. Immunogenetics. 1990;32(5):337-44
• ID
  MGI:43179

Genes

Gene	Assay Type
H2-S	histocompatibility
Orch1	resistance/susceptibility
Tnf	reported elsewhere
H2-D1	histocompatibility

Notes

• Reference
  Authors state Orch1 lies between the gene that governs the antibody response to TNP-Ficoll antigen (Hillstrom-Shapiro, L., et al., J Exp Med 162:1477-1493, 1985) and Tnfa.
• Experiment
  Mice possessing the H2^d and H2^p haplotypes are highly susceptible to autoimmune orchitis (Orch1). Using congenic mice, susceptibility was seen when H2^d alleles are present at or to the right of the H2-S subregion. A significant number of animals with H2^d alleles at the H2-D and H2-L subregions were found resistant, suggesting Orch1 maps within the H2-S/H2-D region. A susceptibility and resistance comparison was studied with known H2-S/H2-D congenic mice and a gene order of H2-S - Orch1 - Tnfa - H2-D was provided.