Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  19
• Reference
  J:102036 Bergren SK, et al., Genetic modifiers affecting severity of epilepsy caused by mutation of sodium channel Scn 2 a. Mamm Genome. 2005 Sep;16(9):683-90
• ID
  MGI:4353905

Genes

Gene
Moe2
D19Mit135

Notes

• Experiment
  The Authors carried out ten backcross generations in transferring the Scn2a<Q54 > transgene onto the C57BL/6J background, thus creating congenic line C57BL/6J.Q54 (abbreviated B6.Q54).
  Further the B6.Q54 congenic mice were crossed to strain SJL/J. Theresulting (SJL X B6)F1.Q54 offspring were abbreviated as F1.Q54. For mapping loci that modified epilepsy the F1.Q54 mice were backcrossed to C57BL/6J. Categorical trait interval mapping with a genome wide scan provided evidence for the existence of twomodifier loci one on mouse Chromosomes 11 and another on mouse 19. Moe1 mapped with Chromosome 11 and showed a peak at 54 cM (95 Mb) and is significantly associated with D11Mit289. The mouse Chromosome 19 locus Moe2 shows a peak at 24 cM (31.3 Mb) andhas a significant association with D19Mit135