About   Help   FAQ
Mapping Data
Experiment
  • Experiment
    TEXT-QTL
  • Chromosome
    6
  • Reference
    J:152067 Shao H, et al., Genetic loci affecting body weight and fatness in a C57BL/6J x PWK/PhJ mouse intercross. Mamm Genome. 2007 Dec;18(12):839-51
  • ID
    MGI:4356334
Genes
GeneAlleleAssay TypeDescription
Bwtq7
D6Mit198
Pfat5
D6Mit284
Notes
  • Experiment
    To determine QTLs effecting body weight C57BL/6J mice were mated to PWK/PhJ and the resulting F2 hybrids were used in mapping. A total of 479 F2 mice (235 female and 244 male) were bred from two types of reciprocal crosses: 236 and 243 F2 mice were obtained from (B6 female X PWK male) F1 Female X (B6 female X PWK male) F1 male crosses and (PWK female X B6 male) F1 female with (B6 female X PWK male) F1 male crosses respectively.

    Four phenotypes were analyzed, these were body weight, lean weight,fat weight, and percent fat (fat weight/body weight X 100). C57BL/6J mice are heavier then PWK/PhJ mice.

    The following new and existing QTLs were mapped
    (following the QTL is the linked peak marker with cM locations):

    Fatq1(D1Mit440 - 54 cM),
    Pbwg1.1(D2Mit285 - 86 cM),
    Adip22 (was identified as Adip10)(D2Mit293 -11cM),
    Gnf5 (D2Mit285 - 86 cM),
    Wt10q4 (was identified as Wt10q2) (D3Mit57 - 55 cM),
    Btwq13 (D3Mit5 - 25cM),
    Afw13 (was identified as Afw1) (D3Mit5 - 25 cM),
    Afpq8 (was identified as Afpq1)(D3Mit256 - 66cM),
    Bw6b (D3Mit17 - 32 cM),
    Epb4.1 (D4Mit17 - 32 cM),
    Adip23 (was identified as Adip11)Adip11 (D4Mit17 -32 cM),
    Bwq8 (D5Mit123- 3cM),
    Bwtq14 (was identified as Bw6d and Bwob) (rs3719351 - 49 cM),
    Afw3 (D5Mit314 - 59 cM),
    Bwtq7 (was identified as Bwtq10)(D6Mit198 - 67 cM),
    Pfat5 (D6Mit284 - 38 cM),
    Pbwg3(D7Mit223 - 72 cM),
    Mtbcq9 (was identified as Mtbcq8)(D9Mit129 - 26 cM),
    Adip21 (was identified as Adip5)(D9Mit123 - 42 cM),
    Adip24 (was identified as Adip15)(D10Mit96 - 56 cM),
    Bw4(D11Mit285 -48 cM),
    Adip19 (D11Mit285 - 52 cM),
    Fatpad3 ( D13Mit144 - 48 cM),
    Bw40 (was identified as Bw10) (D13Mit144 - 48 cM),
    Fatq1 (D16Mit107 - 3 cM)'
    and Adip25 (was identified as Adip17) (D16Mit107 - 3 cM).

    The new QTLs mapped in this study were:
    Bwtq13,
    Bwq13 (alias Bwq8),
    Bwq9 (alias Pbwq1.1),
    Bwq11 (alias Pbwq3),
    Pfat5 (was identified as Pfat2),
    Gnf5 (was identified as Gnf3)
    and Adip19.

    10.03.2014 Curator Note:

    We had originally associated the abdominal fatweight QTL identified here mapping to (D3Mit5- 25 cM) on mouse Chr 3, as Afw1. Afw1 was originally mapped using an outbred cross of DU6 xDUK, in J:49578 in 1998. We consider the current mapping study a separate mapping experiment and have named the QTL identified here as Afw13.

    01.07.2015 Curator Note:

    We had originally associated the QTL identified here, mapping to D13Mit144 - 48 cM as Bw10. However, Bw10 was originally mapped using a different cross, an outbred cross of DU6 x DUK, in J:49578, in 1998. We consider the current mapping study aseparate mapping experiment and have named the QTL identified here as Bw40.

    01.23.2015 Curator Note:

    Because Adip5 was origniallymapped in J:62610 in 2001 using an (LG/J x SM/J) intercross, which differs from the cross used here, we consider the current study a separate mapping experiment and have named this QTL Adip21.

    Adip10, Adip11, Adip15 and Adip17 mentioned here were all originally mapped in J:103841 in 2006 using an (SM/J x NZB/BlNJ)F2 intercross, whichalsodiffers from the cross used here. For thesame reasons noted above we have named these markers Adip22, Adip23, Adip24 and Adip25 respectively.

    03.11.2015 Curator Note:

    Because Bwtq10 was originally mapped in J:103841 in 2006 using (SM/J x NZB/BlNJ)F2 intercross, which differs from thecross usedhere, we consider the current study a separate map experiment and have named this QTL Bwqt7, (D6Mit198- 67 cM).

    04.2.2015 Curator Note:

    Mtbcq8 was originally mapped in J:93070 in 2004 using an (NMRI8/Fbn xDBA/2OlaHsd)F2 intercross, which differs fromthe cross used here, we consider the current study a new map experiment and have named the QTL Mtbcq9 (D9Mit129 - 26cM).

    04.14.2015 Curator Note:

    Because the abdominal fat percent QTL 1, (Afpq1) was orginally mapped in J:49578 in 1998 using an an outbredcross of DU6 xDUK, which differs from the cross used here we consider the current mapping study a separate mapping experiment and have named the QTL Afpq8.

    04.15.2015 Curator Note:

    Because Wt10q2 was originally mapped in J:55483 in 1999 using an (MHxC57BL/6J)F2 intercross, which differs from the cross used here, we consider the current mapping study a separate mapping experiment and have named the QTL Wt10q4.

    06.16.2015 Curator Note:

    Pbwq1.1 was orginally mapped in J:121981 using B6.Cg congenic mice, which differ from the C57BL/6J X PWK/PhJ mice used here. We consider the current mapping study a separate mapping experiment and have named this QTL, mapping to Chr 2 with D2Mit285, Bwq9.

    Pbwq3 was originally mapped in J:88536 using an (C57BL/6J x M. m. castaneus)F1 x M. m. castaneus backcross, which also differs from the cross used here. We have named this QTL, mapping to Chr 7 with D7Mit223, Bwq11.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/19/2024
MGI 6.24
The Jackson Laboratory