Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  5
• Reference
  J:152194 Oikarinen SI, et al., Genetic mapping of Mom5, a novel modifier of Apc(Min)-induced intestinal tumorigenesis. Carcinogenesis. 2009 Sep;30(9):1591-6
• ID
  MGI:4359636

Genes

Gene
D5Mit48
D5Mit348
D5Mit388
Mom5
Rint1

Notes

• Experiment
  A Genetic linkage experiment was carried out to determine if there was a genetic modifier affected the number of intestinal tumors in Apc(min/+) mice. 129P2/OlaHsd (- /Erb) knockout mice were backcrossed to C57BL/6J - Apc(Min/+) mice for 10 generations (N10). At both N5 and N10 Erb(+/-) females were intercrossed with Apc(Min/+) males. Using STS markers linkage was analyzed at N5 whereby 10 of the intercross mice with the fewest intestinal adenomas were mated to 10 with the most intestinal adenomas. A more robust explanation of the linkage cross is reported in the methods section for this cross. The 1.5 LOD support interval ranges from D5Mit48 to D5Mit388 with a peak at D5Mit348. The QTL in this region is defined as Mom5 with Rint1 suggested as a strong candidate