Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  2
• Reference
  J:18309 Hess EJ, et al., Deletion map of the coloboma (Cm) locus on mouse chromosome 2. Genomics. 1994 May 1;21(1):257-61
• ID
  MGI:43712

Genes

Gene	Assay Type
Slc30a4	visible phenotype
Cm	visible phenotype

Notes

• Reference
  The authors use Bmp-2a, Plcb-1 and Nec-2 for Bmp2, Plcb and Pcsk2 respectively. This study identifies two genes, Plcb and Snap, that may be considered candidate genes for Cm.
• Experiment
  To determine whether lm was encompassed in the Cm deletion, a complementation assay was performed with mice from a Cm +/+ + x + lm/+ lm mating. + +/+ lm dams (N = 4) successfully nursed all 27 pups. Cm +/+ lm dams (N = 5) successfully nursed 30 out of 31pups. Because these hybrids produced normal milk it was apparent that lm was complemented by the Cm chromosome and is, therefore outside the Cm deletion.