Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  2
• Reference
  J:18309 Hess EJ, et al., Deletion map of the coloboma (Cm) locus on mouse chromosome 2. Genomics. 1994 May 1;21(1):257-61
• ID
  MGI:43713

Genes

Gene	Assay Type	Description
D2Nds3	PCR amplified length variant	T15
D2Mit70	PCR amplified length variant	B5554
D2Mit77	PCR amplified length variant	B738
D2Mit106	PCR amplified length variant	MPC1901
D2Mit107	PCR amplified length variant	MPC1066
D2Mit19	PCR amplified length variant	A83
D2Mit46	PCR amplified length variant	A657
D2Mit28	PCR amplified length variant	D25
D2Mit136	PCR amplified length variant	MMH149
D2Mit108	PCR amplified length variant	MPC349
D2Mit21	PCR amplified length variant	M184

Notes

• Reference
  The authors use Bmp-2a, Plcb-1 and Nec-2 for Bmp2, Plcb and Pcsk2 respectively. This study identifies two genes, Plcb and Snap, that may be considered candidate genes for Cm.
• Experiment
  Additional markers were mapped to delineate the boundaries of the Cm deletion. The most proximal loci detected within the deletion, D2Mit19 and D2Mit46 have been mapped within about 1.1 cM from D2Mit28, the simple sequence repeat (SSR) within the 3' untranslated region of Snap. Other SSRs mapped to this location, D2Nds3, D2Mit70, D2Mit77, D2Mit106 and D2Mit107, are not included in the deleted region, suggesting that the proximal deletion breakpoint occurs in a small region between the SSR loci D2Nds3, D2Mit70,D2Mit77, D2Mit106, D2Mit107, D2Mit19 and D2Mit46. The distal breakpoint of the Cm deletion between D2Mit28-D2MIt136 and the intact D2Mit108, D2Mit21 loci indicate the maximum size of the deletion is 2.2 cM.