Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  2
• Reference
  J:20685 Serreze DV, et al., Use of recombinant congenic and congenic strains of NOD mice to identify a new insulin-dependent diabetes resistance gene. J Exp Med. 1994 Oct 1;180(4):1553-8
• ID
  MGI:43958

Genes

Gene	Assay Type
B2m	reported elsewhere
Idd13	resistance/susceptibility
Il1	reported elsewhere
Pcna	reported elsewhere
D2Mit47	reported elsewhere
D2Mit48	reported elsewhere

Notes

• Experiment
  The authors describe the derivation of a diabetes resistant mouse strain, NOR/Lt, used in the identification of a new insulin-dependent diabetes susceptibility locus (Idd13) on Chromosome 2. NOR/Lt is a recombinant congenic strain in which portions of the NOD/Lt genome has been replaced by DNA from the C57BL/KsJ strain. Genotypic analysis of the progeny from a (NOD/Lt x NOR/Lt)F2 cross using the Chi square test indicates that Idd13 maps between B2m and Pcna, very near Il1. This location was confirmed by the analysis of congenic strains where Idd13 from the NOR/Lt strain cosegregates with Il1, D2Mit47 and D2Mit48 onto the NOD/Lt background. Together these studies indicate that the order of loci in this region of Chromosome 2 is: B2m, Idd13, Il1, D2Mit47, D2Mit48. Homozygosity for NOR/Lt-derived alleles confer resistance to IDDM at Idd13.