Mapping Data

Experiment

• Experiment
  CROSS
• Chromosome
  17
• Reference
  J:18313 Yoshino M, et al., No dosage effect of recombinational hotspots in the mouse major histocompatibility complex. Immunogenetics. 1994;39(6):381-9
• ID
  MGI:44089

Genes

Gene	Assay Type	Description
H2-K1	immunological
H2-Ab1	Southern analysis	Ab cDNA probe
H2-Eb1	Southern analysis	Eb cDNA probe
H2-Ea	Southern analysis	probe 10
Cyp21a1	Southern analysis	Cyp21a1 genomic2
H2-D1	immunological

Notes

• Reference
  Authors use Cyp21 for Cyp21a1. MHC haplotype wm7 represented by congenics B10.MOL-SGR and B10.A(R209); cas3 by B10.CAS3, B10.CAS3(R1), (R7), (R8) and (R0); and haplotype cas4 by B10.CAS4(R28). Authors determined that the frequency of meiotic recombination was not altered by a genetic double dose of recombination hotspots in the Lmp2 region.
• Experiment
  Female progeny reported here.

CROSS

• Type
  Backcross, sexes unspecified or combined
• Female Parent
  <s> <s> <s> <s> <s> <s>/<c> <c> <c> <c> <c> <c>
• Strain
  (B10.MOL-SGR x B10.CAS3(R7))F1
• Male Parent
  <b> <b> <b> <b> <b> <b>/<b> <b> <b> <b> <b> <b>
• Strain
  C57BL/10, B10.A, B10.BR-H2 or B10.D2
• Allele 1
  s from B10.MOL(SGR)-Prdm9 H2
• Allele 2
  s from B10.CAS3(R7)

CROSS Data

MC #mice	H2-K1	H2-Ab1	H2-Eb1	H2-Ea	Cyp21a1	H2-D1
348	p	p	p	p	p	p
1	s	c	c	c	c	c
1	c	s	s	s	s	s
1	c	c	c	c	s	s
2	s	s	s	s	c	c
1	s	s	s	s	s	c

Statistics

Marker 1	Marker 2	# Recombinants	Total	% Recombinants	Std Error
H2-K1	H2-Ab1	2	354	0.565	0.398
H2-Ab1	H2-Eb1	0	354	0.000	0.000
H2-Eb1	H2-Ea	0	354	0.000	0.000
H2-Ea	Cyp21a1	3	354	0.847	0.487
Cyp21a1	H2-D1	1	354	0.282	0.282