Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  2
• Reference
  J:153376 Kamao T, et al., Genetic dissociation of dacryoadenitis and sialadenitis in a Sjogren's syndrome mouse model with common and different susceptibility gene loci. Invest Ophthalmol Vis Sci. 2009 Jul;50(7):3257-65
• ID
  MGI:4410456

Genes

Gene
Adacm2
D2Mit285
Asm4
D2Mit395
Asm5
D2Mit22

Notes

• Experiment
  MRL/Mp-lpr/lpr mice spontaneously develop progressive dacryoadenitis and
  Sialadenitis. A difference in severity of these diseases is evident when comparing MRL/Mp-lpr/lpr with C3H/lpr mice allowing for the mapping of these traits in a genome wide scan. From these strains, 527 (MRL/lpr _ C3H/lpr) F2 (MCF2) mice were employed for QTL linkage analysis. Phenotypic analysis for dacryoadenitis and sialadenitis indexed for lesions showed that MRL parents showed a much higher degree for lesions as did C3H parents. Further dacryoadenitis and sialadenitis are inherited as recessive in mice with a MRL background. The mapping was indicated in Table 1 of the reference. The following QTL were observed, in parenthesis is chr location, LOD score, nearest marker, and suggested cM location: Autoimmune dacryoadenitis in MRL mice; Adacm1 (Chr.1, LOD 4.0, D1Mit187, 64.1 cM), Adacm2 (Chr.2, LOD 3.7, D2Mit285, 88.4 cM), Adacm3 (Chr.5, LOD 3.1, D5Mit136, 63.9 cM), autoimmune sialadenitis in MRL mice, Asm3 (Chr.1, LOD16.8, D1Mit286, 16.8, 69 cM), Asm4 (Chr.2, LOD 5.6, D2Mit395, 65.3 cM), Asm5 (Chr.2, LOD 5.4,D2Mit22, 82.1 cM).