Experiment
MRL/Mp-lpr/lpr mice spontaneously develop progressive dacryoadenitis and
Sialadenitis. A difference in severity of in these diseases is evident when comparing MRL/Mp-lpr/lpr with C3H/lpr mice allowing for the mapping of these traits in a genome wide scan. From these strains, 527 (MRL/lpr _ C3H/lpr) F2 (MCF2) mice were employed for QTL linkage analysis. Phenotypic analysis for dacryoadenitis and sialadenitis indexed for lesions showed that MRL parents showed a much higher degree for lesions as did C3H parents. Further dacryoadenitis and sialadenitis are inherited as recessive in mice with a MRL background. The mapping was indicated in Table 1 of the reference. The following QTL were observed, in parenthesis is chr location, LOD score, nearest marker and suggested cM location: Autoimmune dacryoadenitis in MRL mice ; Adacm1 (Chr.1, LOD 4.0, D1Mit187, 64.1 cM), Adacm2 (Chr.2, LOD 3.7, D2Mit285, 88.4 cM), Adacm3 (Chr.5, LOD 3.1, D5Mit136, 63.9 cM), autoimmune sialadenitis in MRL mice, Asm3 (Chr.1, LOD16.8, D1Mit286, 16.8, 69 cM), Asm4 (Chr.2, LOD 5.6, D2Mit395, 65.3 cM), Asm5 (Chr.2, LOD 5.4,D2Mit22, 82.1 cM).
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