Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  4
• Reference
  J:18261 Drake CG, et al., Genetic analysis of the NZB contribution to lupus-like autoimmune disease in (NZB x NZW)F1 mice. Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):4062-6
• ID
  MGI:44114

Genes

Gene	Assay Type
D4Nds2	PCR amplified length variant
D4Mit11	PCR amplified length variant
Lck	Southern analysis
D4Mit16	PCR amplified length variant
Epb41	Southern analysis
Nba1	visible phenotype
D4Mit48	PCR amplified length variant

Notes

• Experiment
  The backcross (NZB/BlNJ x NZW/lacJ)F1 x NZW/lacJ was screened for approximately 350 SSLP markers. There was a significant association with the expression of autoimmune renal disease and distal Chromosome 4 markers. Using x² analysis of Nba1, there were6 markers which gave a significant P value (in parenthesis): D4Nds2 (0.005) - D4Mit11 (0.005) - Lck (0.001) - D4Mit16 (0.005) - Epb4.1 (0.0005) - D4Mit48 (0.001). The authors place Nba1 7 cM distal to Lck, between Epb4.1 and D4Mit48. This was based on 7 of the backcross mice with a recombinant between Elp1 and D4Mit48.