Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  7
• Reference
  J:153895 Kemter E, et al., Novel missense mutation of uromodulin in mice causes renal dysfunction with alterations in urea handling, energy, and bone metabolism. Am J Physiol Renal Physiol. 2009 Nov;297(5):F1391-8
• ID
  MGI:4420676

Genes

Gene
Umod

Notes

• Experiment
  Homozygous mutant UREH4 mice (radiation induced)are viable, and they
  grow and reproduce normally however they exhibit a defect in the urine
  concentration mechanism and the excretion of urinary solutes. This defect was mapped mouse Chromosome 7 between 125.2 (rs3690100) and 134.8 Mb (rs31285172). Included within that region is mouse gene Umod. A G-A transversion in exon 3 of Umod was determined as causative of the defect.